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Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature
Author(s) -
Benesch Martin,
Wardelmann Eva,
Ferrari Andrea,
Brennan Bernadette,
Verschuur Arnauld
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22123
Subject(s) - gist , medicine , stromal tumor , stromal cell , general surgery
Standards for the management of gastrointestinal stromal tumors (GIST) in children do presently not exist. Thus a systematic review and summary of the current literature was conducted serving as a basis for the further development of optimal management strategies for childhood GIST within a cooperative network. Presently 21 cases with familial GIST, and more than 100 pediatric cases each with Carney triad or sporadic GIST have been published so far. An international prospective registration based on national registries has recently started to acquire more clinical and molecular data and to develop appropriate management strategies for children and adolescents with GIST. Pediatr Blood Cancer 2009; 53:1171–1179. © 2009 Wiley‐Liss, Inc.