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A case of multisystem Langerhans cell histiocytosis with primary hypothyroidism followed by type 1 diabetes mellitus
Author(s) -
Shima Haruko,
Inokuchi Mikako,
Shimada Hiroyuki
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22066
Subject(s) - medicine , langerhans cell histiocytosis , pancreas , thyroid , histiocytosis , diabetes mellitus , type 2 diabetes mellitus , endocrinology , pathology , gastroenterology , disease
We report a case of a 13‐year‐old female with Langerhans cell histiocytosis (LCH) and primary hypothyroidism followed by type 1 diabetes mellitus (DM), both of which are rare complications. In LCH diagnosis, imaging studies showed an enlargement of the thyroid gland, suggesting the involvement of LCH cells. While the pancreas appeared normal, insulin secretion markedly deteriorated 11 months after cessation of chemotherapy. Even without direct pancreatic involvement, there is a possibility that LCH could induce DM as a part of its long‐term complications. In particular, thyroid involvement may be related to the onset of DM. Pediatr Blood Cancer 2009;53:232–234. © 2009 Wiley‐Liss, Inc.