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Neonatal acute myeloid leukemia in an infant whose mother was exposed to diethylstilboestrol in utero
Author(s) -
Chantrain C.F.,
Sauvage D.,
Brichard B.,
Dupont S.,
Poirel H.A.,
Ameye G.,
De Weer A.,
Vandenberghe P.,
Detaille T.,
Anslot C.,
de Cléty S. Clément,
Vermylen C.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22040
Subject(s) - medicine , leukemia cutis , myeloid leukemia , leukemia , in utero , disseminated intravascular coagulation , acute monocytic leukemia , respiratory distress , transplacental , myeloid , acute leukemia , pregnancy , immunology , fetus , pathology , placenta , surgery , biology , genetics
We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero. The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL‐ELL fusion transcript. Chemotherapy was initiated but the child developed a bilateral pulmonary infection that led to fatal respiratory distress. This case shows acute myeloid leukemia and the third pediatric leukemia reported after maternal diethylstilboestrol exposure. Pediatr Blood Cancer 2009;53:220–222. © 2009 Wiley‐Liss, Inc.