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Wilms tumour and paternal occupation: An analysis of data from the national registry of childhood tumours
Author(s) -
Fear N.T.,
Vincent T.J.,
King J.C.,
MacCarthy A.,
Bunch K.J.,
Murphy M.F.G.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22013
Subject(s) - medicine , wilms tumour , odds ratio , wilms' tumor , childhood cancer , logistic regression , population , cancer registry , confidence interval , odds , demography , pediatrics , cancer , pathology , environmental health , sociology
Background Wilms tumour is an embryonal malignant tumour that accounts for 90% of childhood kidney cancers. Parental occupational exposure has been hypothesised to be a cause of childhood Wilms tumour, in particular exposure to pesticides. However, the findings are inconsistent. Procedure We have examined the association between paternal occupational exposures and Wilms tumour using birth registration data for cases (n = 2568) from the National Registry of Childhood Tumours (NRCT) and matched controls (n = 2,568) drawn from the general population of Great Britain. Paternal occupation, as recorded at the time of birth, was used to infer “occupational exposure” using a previously defined occupational exposure classification scheme. Odds ratios and 95% confidence intervals were generated using conditional logistic regression with exact methods to estimate the association between each paternal occupational exposure group and childhood Wilms tumour. Results All odds ratios were close to 1.00 and no statistically significant associations were observed. Conclusion The results of this study failed to support any of the previously identified associations between paternal occupation and childhood Wilms tumour. Pediatr Blood Cancer 2009;53:28–32. © 2009 Wiley‐Liss, Inc.