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Lactic acidosis and hypoglycemia with ALL relapse following engrafted bone marrow transplant
Author(s) -
Luscri Nathan,
Mauer Michael,
Sarafoglou Kyriakie,
Moran Antoinette,
Tolar Jakub
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22010
Subject(s) - lactic acidosis , medicine , hypoglycemia , acidosis , intensive care medicine , respiratory failure , bone marrow transplant , anesthesia , surgery , bone marrow , bone marrow transplantation , insulin
Lactic acidosis together with hypoglycemia in the face of hematologic malignancy is a grave development. A 7‐year‐old male with pre‐B‐cell ALL following hematopoietic cell transplant was admitted to our hospital in his second relapse. On hospital days 4 and 5, he developed refractory hypoglycemia, lactic acidosis, central respiratory failure, and acute renal failure. Bicarbonate infusion, B vitamins, and hemodialysis were not effective. Care was withdrawn on hospital day 9. Further understanding of the mechanisms that cause the combined onset of lactic acidosis and hypoglycemia will help clinicians in implementing timely therapies that may reduce mortality. Pediatr Blood Cancer 2009;53:223–225. © 2009 Wiley‐Liss, Inc.