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Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors
Author(s) -
Lebensburger Jeffrey,
Katzenstein Howard,
Jenkins Jesse J.,
RodriguezGalindo Carlos
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22005
Subject(s) - medicine , malignancy , osteosarcoma , blood cancer , solitary pulmonary nodule , differential diagnosis , cancer , nodule (geology) , pathology , pediatric cancer , lesion , carcinoma , radiology , lung , paleontology , biology
Second malignancies occur in 2–3% of survivors of pediatric osteosarcoma; treatment‐related hematologic and solid malignancies have both been described. We present two cases of patients with pulmonary nodules that developed more than 2 years after treatment of osteosarcoma. Both lesions were completely resected and pathology revealed bronchioloalveolar carcinoma (BAC). Primary BAC is extremely rare in children; however, cases of this malignancy have been described in survivors of pediatric cancer. BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer. Pediatr Blood Cancer 2009;53:499–501. © 2009 Wiley‐Liss, Inc.