Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors | Zendy

Lebensburger Jeffrey | Zendy; Katzenstein Howard | Zendy; Jenkins Jesse J. | Zendy; RodriguezGalindo Carlos | Zendy

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Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors

Author(s) -

Lebensburger Jeffrey,

Katzenstein Howard,

Jenkins Jesse J.,

RodriguezGalindo Carlos

Publication year - 2009

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.22005

Subject(s) - medicine , malignancy , osteosarcoma , blood cancer , solitary pulmonary nodule , differential diagnosis , cancer , nodule (geology) , pathology , pediatric cancer , lesion , carcinoma , radiology , lung , paleontology , biology

Second malignancies occur in 2–3% of survivors of pediatric osteosarcoma; treatment‐related hematologic and solid malignancies have both been described. We present two cases of patients with pulmonary nodules that developed more than 2 years after treatment of osteosarcoma. Both lesions were completely resected and pathology revealed bronchioloalveolar carcinoma (BAC). Primary BAC is extremely rare in children; however, cases of this malignancy have been described in survivors of pediatric cancer. BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer. Pediatr Blood Cancer 2009;53:499–501. © 2009 Wiley‐Liss, Inc.

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