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Neonatal alloimmune thrombocytopenia due to HPA‐9b incompatibility
Author(s) -
Raj Ashok,
Kailasnath Vasundhara P.,
Bertolone Salvatore,
McFarland Janice G.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21997
Subject(s) - neonatal alloimmune thrombocytopenia , medicine , antigen , platelet , blood cancer , fetus , immunology , antibody , typing , sensitization , pregnancy , cancer , genetics , biology
Abstract Neonatal alloimmune thrombocytopenia (NAIT) is one of the most frequent causes of both severe thrombocytopenia and intracranial hemorrhage (ICH) in fetuses and term neonates. The diagnosis is established by demonstrating antibodies against human platelet antigens (HPA) and discordance in platelet antigen typing between parents or between the mother and neonate. We report a case of NAIT that was likely due to maternal sensitization to HPA‐9b (Max a ), a recently recognized, rare platelet‐specific antigen. Pediatr Blood Cancer 2009;53:459–461. © 2009 Wiley‐Liss, Inc.