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Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies
Author(s) -
Gramatges M. Monica,
Fani Pauline,
Nadeau Kari,
Pereira Shalini,
Jeng Michael R.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21979
Subject(s) - neonatal alloimmune thrombocytopenia , medicine , neutropenia , immunology , antibody , human leukocyte antigen , antigen , platelet , pregnancy , fetus , biology , chemotherapy , genetics
Neonatal thrombocytopenia or neutropenia may result from passive transfusion of maternally derived antibodies. Antibodies against platelet antigens are commonly associated with neonatal alloimmune thrombocytopenia (NAIT), and anti‐neutrophil antibodies are frequently identified in alloimmune neonatal neutropenia (ANN). Combined alloimmune cytopenias in the newborn are rarely reported; even fewer reports document human leukocyte antigen (HLA) antibodies as a potential cause of neonatal thrombocytopenia or neutropenia. We describe neutropenia and thrombocytopenia in a newborn associated with markedly elevated maternal HLA antibodies in the absence of anti‐neutrophil or anti‐platelet antibodies to highlight consideration of HLA antibodies in the pathogenesis of ANN and NAIT. Pediatr Blood Cancer 2009;53:97–99. © 2009 Wiley‐Liss, Inc.