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Wilms tumor, AML and medulloblastoma in a child with cancer prone syndrome of total premature chromatid separation and Fanconi anemia
Author(s) -
Sari Neriman,
Akyuz Canan,
Aktas Dilek,
Gumruk Fatma,
Orhan Diclehan,
Alikasifoglu Mehmet,
Aydin Burca,
Alanay Yasemin,
Buyukpamukcu Munevver
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21966
Subject(s) - fanconi anemia , medulloblastoma , medicine , chromatid , wilms' tumor , chromosome instability , leukemia , aneuploidy , anemia , bloom syndrome , myeloid leukemia , cancer , cancer research , pathology , genetics , biology , dna repair , chromosome , gene , helicase , rna
Wilms tumor (WT) is the most common primary renal tumor in childhood. The occurrence of WT in patients with growth retardation, mental retardation and central nervous system abnormalities in association with premature chromatid separation (PCS) and mosaic variegated aneuploidy has been previously described in only 10 patients. Here we report the very rare occurrence of WT with two other malignancies, acute myeloid leukemia and medulloblastoma in association with chromosomal instability. This is a novel presentation of Fanconi anemia with this cytogenetic abnormality. Pediatr Blood Cancer 2009;53:208–210. © 2009 Wiley‐Liss, Inc.