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KIR–HLA receptor‐ligand mismatch associated with a graft‐versus‐tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors
Author(s) -
PérezMartínez Antonio,
Leung Wing,
Muñoz Evangelina,
Iyengar Rekha,
Ramírez Manuel,
Vicario José Luis,
Lassaletta Álvaro,
Sevilla Julián,
GonzálezVicent Marta,
Madero Luis,
DíazPérez Miguel Ángel
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21955
Subject(s) - human leukocyte antigen , medicine , immunology , transplantation , receptor , refractory (planetary science) , antigen , cancer research , biology , astrobiology
Killer immunoglobulin‐like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR–HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. Pediatr Blood Cancer 2009;53:120–124. © 2009 Wiley‐Liss, Inc.