Simultaneous occurrence of  MLL  and  RARA  rearrangements in a pediatric acute lymphoblastic leukemia patient | Zendy

Zámečníkova Adriana | Zendy; Al Bahar Soad | Zendy

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Simultaneous occurrence of MLL and RARA rearrangements in a pediatric acute lymphoblastic leukemia patient

Author(s) -

Zámečníkova Adriana,

Al Bahar Soad

Publication year - 2009

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.21915

Subject(s) - chromosomal translocation , breakpoint , fluorescence in situ hybridization , acute promyelocytic leukemia , leukemia , medicine , chromosome , comparative genomic hybridization , chromosomal rearrangement , lymphoblastic leukemia , karyotype , gene , cancer research , genetics , biology , microbiology and biotechnology , retinoic acid

We report a case of concurrent translocations of MLL gene, associated with a highly distinct leukemia subtype and RARA gene, which is pathogenomic in acute promyelocytic leukemia. Conventional cytogenetic revealed a novel complex rearrangement between chromosomes 5, 11, and 17 resulting in a three‐way chromosome translocation t(5;11;17)(q31;q23;q21). Fluorescence in situ hybridization analysis demonstrated that the 11q23 breakpoint involved the MLL , and the 17q21 breakpoint involved the RARA gene. Concurrent translocations of two specific oncogenes MLL and RARA with a new partner breakpoint on 5q31 have not been previously described. Pediatr Blood Cancer 2009;52:671–674. © 2009 Wiley‐Liss, Inc.

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