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Unrelated stem cell transplant for infantile idiopathic myelofibrosis
Author(s) -
Domm Jennifer,
Calder Cassie,
Manes Becky,
Crossno Christine,
Correa Hernan,
Frangoul Haydar
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21910
Subject(s) - medicine , myelofibrosis , blood cancer , stem cell , disease , bone marrow transplant , pediatrics , bone marrow , bone marrow transplantation , cancer , pathology , biology , genetics
Idiopathic myelofibrosis (IMF) is a rare disease in children that can present during infancy and have a protracted course. The only known curative approach for this disease in adult patients is allogeneic stem cell transplant. We present two cases of IMF during infancy that did not resolve with supportive care measures. Both patients underwent unrelated stem cell transplant with complete resolution of their hematologic manifestations and resolution of the bone marrow fibrosis. Pediatr Blood Cancer 2009;52:893–895. © 2009 Wiley‐Liss, Inc.