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Acquired factor VII deficiency associated with Wilms tumor
Author(s) -
Granger Jeremy,
Gidvani Vinod K.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21900
Subject(s) - medicine , wilms' tumor , partial thromboplastin time , coagulopathy , prothrombin time , fresh frozen plasma , gastroenterology , coagulation , platelet
We present the case of a 2‐year‐old female with Wilms tumor whose initial evaluation revealed a prolonged prothrombin time (PT) and normal activated partial thromboplastin time. Mixing studies demonstrated correction of the PT and the Factor VII activity was 17% in the absence of a Factor VII inhibitor. She underwent successful resection of the tumor with fresh frozen plasma support and no excessive bleeding. Post‐operative testing demonstrated normal PT at 3 days and 1‐month. Although acquired von Willebrand factor deficiency has a known association with Wilms tumor, paraneoplastic factor VII deficiency associated with Wilms tumor is previously unreported. Pediatr Blood Cancer 2009;52:394–395. © 2008 Wiley‐Liss, Inc.