Premium
False‐photosensitivity and transient hemiparesis following high‐dose intravenous and intrathecal methotrexate for treatment of acute lymphoblastic leukemia
Author(s) -
Shah Nilay,
Zambidis Elias T.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21896
Subject(s) - medicine , methotrexate , lymphoblastic leukemia , hemiparesis , intrathecal , photosensitivity , acute lymphocytic leukemia , anesthesia , etiology , allergic reaction , leukemia , surgery , allergy , immunology , lesion , physics , quantum mechanics
We describe a patient who was treated with high‐dose intravenous and intrathecal methotrexate for acute lymphoblastic leukemia, and who manifested a false photosensitivity reaction with no prior evidence of sun exposure. This patient later experienced delayed transient hemiparesis following methotrexate administration, although without long‐term sequelae. The etiology of these events is obscure, but suggestive of a vasculitic or immune‐mediated reaction to methotrexate. Pediatr Blood Cancer 2009;53:103–105. © 2009 Wiley‐Liss, Inc.