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Pre‐freeze and post‐thaw characteristics on chimerism patterns in double‐unit cord blood transplantation
Author(s) -
Jaing TangHer,
Tsay PeiKwei,
Lin TungLiang,
Yang ChaoPing,
Hung IouJih,
Wen YuChuan
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21882
Subject(s) - medicine , cord blood , transplantation , cd34 , cord , cell , urology , immunology , gastroenterology , andrology , surgery , stem cell , biology , genetics
We analyzed the pre‐freeze and post‐thaw characteristics on chimerism patterns in 20 cases of double‐unit cord blood transplantation. The cord blood units (CBUs) were a 4/6 HLA match or better with recipients and achieved a minimum combined precryopreservation cell dose of 3.7 × 10 7 total nucleated cell (TNC)/kg. The unit with a higher cell dose was infused first. All evaluable patients engrafted at a median of 18 days. By day 42, neutrophil engraftment was derived from both donors in 63% of cases and a single donor in 37% of patients. By day 100, one unit predominated in 80% of the patients. Higher pre‐freeze TNC and CD34+ cell doses were associated with cord predominance in 67% of patients. Pediatr Blood Cancer 2009;52:547–550. © 2008 Wiley‐Liss, Inc.