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3q27 aberrations in a childhood ovary teratoma with associated malignant germ cell component
Author(s) -
Brassesco María Sol,
CastroGamero Angel Mauricio,
Valera Elvis Terci,
Neder Luciano,
Elias Jorge,
Tone Luiz Gonzaga
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21877
Subject(s) - loss of heterozygosity , ovary , teratoma , germ cell , karyotype , biology , ovarian teratoma , pathology , immature teratoma , ovarian cancer , cytogenetics , dysgerminoma , medicine , germ cell tumors , cancer research , cancer , genetics , gene , chromosome , allele , chemotherapy
Cytogenetic studies of childhood ovary tumors have been poorly described. In the present article, the cytogenetic findings of an ovarian teratoma with malignant germ cell (yolk‐sac) component occurring in an 8‐year‐old female are detailed. GTG‐banding showed a karyotype of 46,XX, t(3;20)(q27;q13.3) [4]/46,XX, del3q27 [3]/46,XX [30]. Previous studies have demonstrated common sites of loss of heterozygosity at 3q27‐q28 region in different types of cancer, suggesting the presence of tumor suppressor genes within this region. Pediatr Blood Cancer 2009;52:398–401. © 2008 Wiley‐Liss, Inc.