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Successful treatment of central nervous system juvenile xanthogranulomatosis with cladribine
Author(s) -
Rajendra Barathi,
Duncan Alison,
Parslew Richard,
Pizer Barry L.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21830
Subject(s) - medicine , cladribine , vinblastine , prednisolone , lesion , central nervous system , histiocyte , dermatology , pathology , chemotherapy
Juvenile xanthogranulomatosis (JXG) is an uncommon histiocytic disease that is usually limited to the skin. Here we describe an infant with systemic JXG including a central nervous system (CNS) lesion. He was initially treated with prednisolone and vinblastine but developed an idiosyncratic reaction to prednisolone that was discontinued. The lesion then failed to respond to vinblastine monotherapy. Treatment with cladribine (2‐chlorodeoxyadenosine) was subsequently successful with radiological resolution of the CNS lesion. Pediatr Blood Cancer 2009;52:413–415. © 2008 Wiley‐Liss, Inc.