Premium
Renal cell carcinoma in the pediatric population: Results from the California Cancer Registry
Author(s) -
Silberstein Jonathan,
Grabowski Julia,
Saltzstein Sidney L.,
Kane Christopher J.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21779
Subject(s) - medicine , incidence (geometry) , pacific islanders , renal cell carcinoma , epidemiology , cancer registry , population , cancer , wilms' tumor , disease , pediatrics , physics , environmental health , optics
Background Renal cell carcinoma (RCC) is a rare disease in children and adolescents. This study aimed to review epidemiologic characteristics and survival for pediatric RCC patients using a large, population‐based database. Procedure The California Cancer Registry (CCR) was reviewed from 1988 to 2004. All cases of RCC in patients younger than 21 years were identified and annual age‐adjusted incidence rates were determined for the overall population and subdivided by ethnicity. Tumors were classified by stage and grade, and actuarial mortality rates were calculated. Results From 1988 to 2004, 43 cases of RCC were identified in patients younger than 21 years, accounting for 4.3% of all renal tumors in this age group. The overall annual age‐adjusted incidence was 0.01/100,000 with the tumor more common in non‐Hispanic blacks (0.03/100,000) compared to non‐Hispanic whites (0.01/100,000), Hispanics (<0.01/100,000), and non‐Hispanic Asians/Pacific Islanders (<0.01/100,000). The mean age at presentation was 15.4 years (SD 4.03, SE 0.615). RCC was identified more frequently in females (58.14%). At the time of presentation, 53.49% of tumors were localized, 20.93% were regionally advanced, and 25.58% were metastatic. The observed actuarial survival at 5 and 10 years was 61% (±15.7%). Conclusion Pediatric RCC is an uncommon and aggressive tumor that occurs most frequently in children in the second decade of life, more often in females and blacks. The epidemiological characteristics of this tumor differ from adult RCC and Wilms tumor, suggesting its distinctive biology and potential need for alternative treatment strategies. Pediatr Blood Cancer 2009;52:237–241. © 2008 Wiley‐Liss, Inc.