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Complete response to tacrolimus in a child with severe aplastic anemia resistant to cyclosporin A
Author(s) -
Macartney Christine,
Freilich Marshall,
Odame Isaac,
Charpentier Karen,
Dror Yigal
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21751
Subject(s) - medicine , tacrolimus , aplastic anemia , anemia , gastroenterology , immunology , transplantation , bone marrow
Aplastic anemia (AA) is a rare disorder in children, usually treated with immunosuppressive therapy (IST) including antithymocyte globulin (ATG) and cyclosporin A. There are no current widely used alternative therapies with comparable efficacy. We describe a child with severe aplastic anemia (SAA), who developed severe gingival hyperplasia secondary to cyclosporin A, unresponsive to intensive dental intervention. When IST was changed to tacrolimus there was a significant improvement in the gingival hyperplasia, but equally important, he achieved complete response of his AA within several months. The use of tacrolimus in children with AA may be a potential modality of treatment. Pediatr Blood Cancer 2009;52:525–527. © 2008 Wiley‐Liss, Inc.