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Differential diagnosis of lipoma‐like lipoblastoma
Author(s) -
Morerio Cristina,
Nozza Paolo,
Tassano Elisa,
Rosanda Cristina,
Granata Claudio,
Conte Massimo,
Panarello Claudio
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21747
Subject(s) - lipoblastoma , lipoma , fluorescence in situ hybridization , medicine , differential diagnosis , pathology , fish <actinopterygii> , gene , biology , genetics , chromosome , fishery
Lipoblastomas are rare benign tumors of white fatty tissue that occur primarily in young children. Occasionally, heterogeneity of morphological appearance and histological overlap with other lipogenic tumors are described. In such cases fluorescence in situ hybridization (FISH) analysis of PLAG1 , a gene specifically rearranged in lipoblastoma, is necessary to prevent misdiagnosis. We present a case of lipoblastoma arising in an atypical site with histological features characteristic of lipoma. The correct diagnosis was made possible on cytogenetic grounds through the identification of the characteristic PLAG1‐HAS2 fusion gene, thus allowing an appropriate clinical approach. Pediatr Blood Cancer 2009;52:132–134. © 2008 Wiley‐Liss, Inc.