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Neurocognitive late effects of chemotherapy in children: The past 10 years of research on brain structure and function
Author(s) -
Anderson Fiona S.,
KuninBatson Alicia S.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21700
Subject(s) - neurocognitive , medicine , chemotherapy , survivorship curve , childhood cancer , blood cancer , cognition , mechanism (biology) , pediatrics , intensive care medicine , oncology , cancer , psychiatry , philosophy , epistemology
Advances in the treatment of childhood cancers have greatly improved survivorship. Success has not come without cost, however, as survivors are at risk for late effects of treatment, including neurocognitive late effects (e.g., difficulties with thinking and reasoning). In the advent of chemotherapy‐only protocols, researchers are examining neurocognitive sequelae of these agents to understand the specific role of chemotherapy in neurocognitive changes and the mechanism through which these occur. In this review, we examine the state of the literature on neurocognitive late effects after chemotherapy and their proposed neural mechanisms. Pediatr Blood Cancer 2009;52:159–164. © 2008 Wiley‐Liss, Inc.