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Vincristine pharmacokinetics in children with down syndrome
Author(s) -
Lönnerholm Gudmar,
Frost BrittMarie,
Söderhäll Stefan,
de Graaf Siebold S.N.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21691
Subject(s) - vincristine , medicine , pharmacokinetics , blood cancer , dosing , oncology , pediatrics , pharmacology , cancer , chemotherapy , cyclophosphamide
Children with Down syndrome (DS), who represent about 2% of childhood acute lymphoblastic leukemia, have inferior prognosis compared to non‐DS children. For vincristine (and many other anticancer agents) pharmacokinetic data are scant or missing, and there is considerable uncertainty about the optimal dosing of drugs to patients with DS. We studied vincristine pharmacokinetics on treatment day one in six children with DS and compared to 92 non‐DS children. No differences were found. Thus, we found no rationale for dose reduction of vincristine in DS children from a strictly pharmacokinetic point of view. Pediatr Blood Cancer 2009;52:123–125. © 2008 Wiley‐Liss, Inc.