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Congenital Ewing sarcoma in retroperitoneum with multiple metastases
Author(s) -
Saito Yusuke,
Matsuzaki Akinobu,
Suminoe Aiko,
Koga Yuhki,
Kurata Hiroaki,
Oda Yoshinao,
Tsuneyoshi Masazumi,
Hara Toshiro
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21678
Subject(s) - medicine , blood cancer , sarcoma , pathology , spinal canal , ewing's sarcoma , presentation (obstetrics) , radiation therapy , cancer , radiology , spinal cord , psychiatry
A 7‐day‐old Japanese female showed the absence of spontaneous movement in her both legs. MRI revealed tumors in the retroperitoneum invading into the spinal canal, the left cerebral hemisphere and the right eyeball. Histological examination of retroperitoneal tumor revealed the sheets of undifferentiated small round cells with hyperchromatic nuclei and scanty cytoplasm. EWS‐FLI1 fusion gene was detected by RT‐PCR, indicating Ewing sarcoma. She received chemo‐radiotherapy and survived for 2 years and 10 months despite the multiple metastases at initial presentation. Pediatr Blood Cancer 2008;51:698–701. © 2008 Wiley‐Liss, Inc.