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Intracerebral small round cell tumor: An unusual case with EWS‐WT1 translocation
Author(s) -
Bouchireb Karim,
Auger Nathalie,
Bhangoo Ranjeev,
Di Rocco Federico,
Brousse Nicole,
Delattre Olivier,
Varlet Pascale,
Grill Jacques
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21648
Subject(s) - desmoplastic small round cell tumor , stroma , pathology , medicine , immunohistochemistry , differential diagnosis , chromosomal translocation , mesenchymal stem cell , histology , cancer research , gene , biology , biochemistry
Desmoplastic small round cell tumor (DSRCT) is a rare tumor, seen both in children and young adults with a marked predilection for the peritoneal cavity. Histology showed a small round cell tumor with a fibromyxoïd stroma and immunohistochemistry indicated neural and mesenchymal differentiation, and diagnosis was made by molecular detection of the EWS‐WT1 fusion gene product. DSRCT should be considered in the differential diagnosis of intracranial small round cell tumors. Pediatr Blood Cancer 2008;51:545–548. © 2008 Wiley‐Liss, Inc.