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Isolated central nervous system recurrence of acute promyelocytic leukemia in children
Author(s) -
Chow Jessica,
Feusner James
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21608
Subject(s) - medicine , blood cancer , acute promyelocytic leukemia , incidence (geometry) , central nervous system , pediatrics , pathogenesis , leukemia , intrathecal , oncology , cancer , surgery , gene , retinoic acid , biochemistry , chemistry , physics , optics
The incidence of isolated central nervous system (iCNS) relapse in pediatric acute promyelocytic leukemia (APL) is debated. We analyzed the literature, focusing on clinical trials reported since the advent of ATRA use. Only 2/218 (0.92%) good risk patients (diagnostic WBC <10,000/µl) had truly iCNS relapse. This incidence does not support the use of intrathecal CNS prophylaxis for all children with APL. We also identified multiple deficiencies in these reports. Additional reporting of these events could provide insight into the true incidence and pathogenesis of iCNS relapse and might allow for identification of risk factors associated with such extramedullary relapse. Pediatr Blood Cancer 2009;52:11–13. © 2008 Wiley‐Liss, Inc.