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Lumbar spinal fluid collections in children treated with intrathecal chemotherapy: Elevated CSF protein as a diagnostic clue
Author(s) -
Almanjomi Fahd,
Armstrong Derek,
Abla Oussama,
Naqvi Ahmed,
Weitzman Sheila,
Hitzler Johann
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21592
Subject(s) - medicine , intrathecal , cerebrospinal fluid , ommaya reservoir , chemotherapy , complication , lumbar puncture , lumbar , cerebral spinal fluid , blood cancer , lymphoblastic leukemia , anesthesia , surgery , cancer , leukemia
Subdural fluid collections can interfere with the effective intrathecal administration of chemotherapy by lumbar puncture (LP). We detected this complication in six children who were treated for acute lymphoblastic leukemia (ALL) and presented with an elevated protein concentration of the cerebrospinal fluid (CSF) during routine LP. Contrary to expectation the lumbar fluid collections persisted in two cases and in one case required the insertion of an Ommaya reservoir to continue intrathecal chemotherapy. Awareness and detection of this complication by imaging is important because of its potential to interfere with effective CNS‐directed chemotherapy of ALL. Pediatr Blood Cancer 2008;51:295–298. © 2008 Wiley‐Liss, Inc.