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Severe hypercholesterolemia mediated by lipoprotein X in a pediatric patient with chronic graft‐versus‐host disease of the liver
Author(s) -
Zidan Hanaa,
Lo Stanley,
Wiebe Donald,
Talano Julie,
Alemzadeh Ramin
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21522
Subject(s) - medicine , cholestasis , lipoprotein , gastroenterology , graft versus host disease , blood cancer , cholesterol , bone marrow , disease , cancer
We describe a case of extreme hypercholesterolemia, mediated by lipoprotein X, in a 12‐year‐old Caucasian female who underwent an unrelated allogenic bone marrow transplant for relapsed acute myelocytic leukemia (AML). Her post‐transplant course was complicated by severe chronic graft‐versus‐host disease (GVHD) of the liver. Previously normal serum cholesterol and triglycerides rose to 1,122 mg/dl (29.0 mmol/L) and 1,100 mg/dl (12.4 mmol/L), respectively. Serum cholesterol appeared to be dominantly carried by lipoprotein X. Intra‐hepatic cholestasis leading to reflux of bile lipoproteins into the blood stream and subsequent formation of lipoprotein X appears to be the mechanism underlying this phenomenon. Pediatr Blood Cancer 2008;50:1280–1281. © 2008 Wiley‐Liss, Inc.