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Late relapse of embryonal rhabdomyosarcoma, botryoid variant, of the vagina
Author(s) -
Vasquez Roberto,
Collini Paola,
Meazza Cristina,
Favini Francesca,
Casanova Michela,
Ferrari Andrea
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21482
Subject(s) - medicine , embryonal rhabdomyosarcoma , vagina , rhabdomyosarcoma , estrogen , menarche , estrogen receptor , oncology , gynecology , pathology , sarcoma , surgery , cancer , breast cancer
We report on two very similar cases of vaginal embryonal RMS, botryoid variant, that relapsed 9 and 10 years after initial diagnosis, a few months after the menarche in both cases. A possible causal association with estrogen hormones is hypothesized, particularly for the second case described, in which estrogen receptors were negative in the primary tumor specimen and positive in the relapsing tumor specimen. Pediatr Blood Cancer 2008;51:140–141. © 2008 Wiley‐Liss, Inc.