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Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea
Author(s) -
Singh Sharon A.,
Koumbourlis Anastassios C.,
Aygun Banu
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21480
Subject(s) - medicine , hypoxemia , acute chest syndrome , sickle cell anemia , blood cancer , anemia , disease , pediatrics , cancer
Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly after they were treated with hydroxyurea despite having additional risk factors for hypoxemia. A prospective trial is warranted to assess whether there is a therapeutic effect from the use of hydroxyurea in pediatric SCA patients with chronic hypoxemia. Pediatr Blood Cancer 2008;50:1258–1260. © 2008 Wiley‐Liss, Inc.