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CD‐34 selected hematopoetic stem cell transplantation from HLA identical family members for fanconi anemia
Author(s) -
Balci Yasemin Isik,
Akdemir Yasemin,
Gumruk Fatma,
Cetin Mualla,
Arpaci Fikret,
Uckan Duygu
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21424
Subject(s) - fanconi anemia , fludarabine , medicine , transplantation , stem cell , bone marrow failure , human leukocyte antigen , hematopoietic stem cell transplantation , savior sibling , immunology , total body irradiation , bone marrow , incidence (geometry) , aplastic anemia , anemia , oncology , haematopoiesis , chemotherapy , cyclophosphamide , dna repair , genetics , biology , antigen , physics , optics , gene
Hematopoetic stem cell transplantation, even from an HLA 6/6 identical family member is associated with an increased frequency of complication in fanconi anemia (FA). The increased susceptibility for chromosomal breaks has been suggested as a contributory factor for increased risk of toxicity, graft versus host disease (GVHD) and increased incidence of post‐transplant solid tumors. Therefore, non‐irradiation based preparative regimens usually containing fludarabine and T‐cell depletion of HLA geno‐identical bone marrow cells have increasingly been used in patients with FA. Here, we report three children with FA who underwent CD‐34 selected HSCT from HLA‐identical family donors with reduced intensity fludarabine‐based regimen. Pediatr Blood Cancer 2008;50:1065–1067. © 2007 Wiley‐Liss, Inc.