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Transient sialoadenitis: A complication of 131 I‐metaiodobenzylguanidine therapy
Author(s) -
Modak Shakeel,
PanditTaskar Neeta,
Kushner Brian H.,
Kramer Kim,
SmithJones Peter,
Larson Steven,
Cheung NaiKong V.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21391
Subject(s) - medicine , complication , blood cancer , dysphagia , neuroblastoma , toxicity , gastroenterology , surgery , nuclear medicine , cancer , biology , genetics , cell culture
Radioiodinated metaiodobenzylguanidine [ 131 I‐MIBG] is commonly used to treat resistant neuroblastoma or metastatic pheochromocytoma [MP] with little non‐hematopoietic toxicity. We describe here transient sialoadenitis, a previously unreported complication. Ten patients [9 neuroblastoma and 1 MP] received 12–18 mCi/kg of 131 I‐MIBG. Five patients had bilateral parotid swelling, two with associated buccal discomfort within 24 hr of injection which subsided within 48 hr. Grade 3 or 4 serum amylase elevation was documented in 8/8 patients tested [median 1,336; range: 576–8,830 U/L] which normalized [25–125 U/L] within 4–14 [median 5.5] days. Serum lipase remained normal. Patients did not develop subsequent dry mouth or dysphagia. Pediatr Blood Cancer 2008;50:1271–1273. © 2007 Wiley‐Liss, Inc.