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Graft versus leukemia effect after haploidentical HSCT in a MLL‐negative infant AML with HLXB9/ETV6 rearrangement
Author(s) -
Hauer Julia,
Tosi Sabrina,
Schuster Friedhelm R.,
Harbott Jochen,
Kolb HansJochem,
Borkhardt Arndt
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21376
Subject(s) - medicine , etv6 , myeloid leukemia , hematopoietic stem cell transplantation , leukemia , oncology , haematopoiesis , stem cell , chromosomal translocation , complete remission , immunology , pediatrics , transplantation , chemotherapy , gene , chemistry , biochemistry , genetics , biology
Recently published data show an extremely poor survival of infants with AML and HLXB9/ETV6 rearrangement which is the fusion, resulting from the translocation t(7;12)(q36;p13). None of the patients reported survived a period of 3 years, including four patients who have received allogeneic hematopoietic stem cell transplantation (HSCT). Herein, we report the clinical course of an 8‐month‐old patient with acute myeloid leukemia, M2 subtype and with a HLXB9/TEL rearrangement. The patient received a haploidentical HSCT in relapse situation without any prior re‐induction. The patient became MRD‐negative over a period of 53 days after HSCT. This case reinforces the potential benefit of a graft‐versus‐leukemia effect in the haploidentical setting even in chemoresistant myeloid leukemias with poor‐prognosis molecular features. Pediatr Blood Cancer 2008;50:921–923. © 2007 Wiley‐Liss, Inc.