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Chronic metastatic neuroblastoma
Author(s) -
Kazanowska Bernarda,
Reich Adam,
Jelen Michal,
Chybicka Alicja
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21366
Subject(s) - medicine , neuroblastoma , nodule (geology) , histology , blood cancer , disease , urinary system , pathology , cancer , paleontology , genetics , biology , cell culture
The diversity of neuroblastoma and its clinical course depends on histology, biology and clinical features. We report a male presenting at 4 months of age with an abdominal mass and multiple subcutaneous nodules. The diagnosis was made by histological examination of a subcutaneous nodule and elevated urinary markers. The patient remained well during the subsequent 9 years. During that time no cytostatic treatment was given. Attempt to treat with cis ‐retinoic acid 10 years later did not result in any significant change of the clinical course. The patient has remained in good clinical condition for a 15‐year observation period, having both progressing and regressing distant subcutaneous metastases. Skin nodules are the hallmarks of the indolent clinical course of the disease. We suggest the use of the “chronic neuroblastoma” as a term to describe patients with neuroblastoma showing indolent disease course over a very long period of time, but never achieving complete remission. Pediatr Blood Cancer 2008;50:898–900. © 2007 Wiley‐Liss, Inc.