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Correction of chronic granulomatous disease after second unrelated‐donor umbilical cord blood transplantation
Author(s) -
Parikh Suhag H.,
Szabolcs Paul,
Prasad Vinod K.,
Lakshminarayanan Sonali,
Martin Paul L.,
Driscoll Timothy A.,
Kurtzberg Joanne
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21365
Subject(s) - medicine , chronic granulomatous disease , umbilical cord , immunosuppression , hematopoietic stem cell transplantation , transplantation , surgery , cord blood , umbilical cord blood transplantation , regimen , conditioning regimen , stem cell , haematopoiesis , disease , immunology , biology , genetics
Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for chronic granulomatous disease (CGD), but many patients lack a suitably matched related donor. We report successful outcomes after mismatched, unrelated‐donor umbilical cord blood transplantation (uUCBT) in two boys with X‐linked CGD. Both patients experienced autologous recovery after first transplants, required second transplants to achieve durable donor engraftment, and are alive 27 and 15 months post‐transplant. Both had invasive fungal disease and received granulocyte transfusions. In conclusion, uUCBT is effective in children with CGD, but immunosuppression in the conditioning regimen may need to be increased to decrease the risk of graft rejection. Pediatr Blood Cancer © 2007 Wiley‐Liss, Inc.