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Changing trends of research and treatment in infant neuroblastoma
Author(s) -
Friedman Gregory K.,
Castleberry Robert P.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21354
Subject(s) - neuroblastoma , medicine , malignancy , pediatrics , pediatric cancer , blood cancer , cancer , categorization , oncology , genetics , biology , cell culture , philosophy , epistemology
Neuroblastoma is the most common malignancy in infants and 40% of neuroblastomas are diagnosed in the first year of life. While generally neuroblastoma behaves less aggressively in this age group, tumors that have adverse biologic characteristics do not differ in their behavior from counterparts in older children. Clinical and biologic behavior of neuroblastoma in children up to 460 days of age is similar to that in children less than 1 year of age. Thus the categorization of children up to 18 months of age into risk category is critically dependent on biologic characterization and assignment to appropriate treatment intensity categories. Pediatr Blood Cancer 2007;49:1060–1065. © 2007 Wiley‐Liss, Inc.