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Non‐myeloablative transplantation for severe congenital neutropenia
Author(s) -
Thachil Jecko,
Caswell Mark,
BoltonMaggs Paula H.B.,
Pizer Barry,
Keenan Russell
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21295
Subject(s) - medicine , congenital neutropenia , neutropenia , granulocyte colony stimulating factor , refractory (planetary science) , granulocyte , transplantation , stem cell , blood cancer , absolute neutrophil count , cancer , surgery , chemotherapy , physics , astrobiology , biology , genetics
Severe Congenital Neutropenia is a rare condition characterized by a very low neutrophil count, which pre‐disposes the affected child to recurrent bacterial infections. Treatment with granulocyte colony stimulating factor (G‐CSF) has dramatically improved the prognosis of these children; but in patients who have become G‐CSF refractory, hematopoeitic stem cell transplant is still the only effective curative treatment. We describe a patient who was unresponsive to escalating doses of G‐CSF and underwent a successful reduced intensity conditioning, matched unrelated donor allograft resulting in cure. Pediatr Blood Cancer 2008;50:920–921. © 2007 Wiley‐Liss, Inc.