Non‐myeloablative transplantation for severe congenital neutropenia | Zendy

Thachil Jecko | Zendy; Caswell Mark | Zendy; BoltonMaggs Paula H.B. | Zendy; Pizer Barry | Zendy; Keenan Russell | Zendy

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Non‐myeloablative transplantation for severe congenital neutropenia

Author(s) -

Thachil Jecko,

Caswell Mark,

BoltonMaggs Paula H.B.,

Pizer Barry,

Keenan Russell

Publication year - 2008

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.21295

Subject(s) - medicine , congenital neutropenia , neutropenia , granulocyte colony stimulating factor , refractory (planetary science) , granulocyte , transplantation , stem cell , blood cancer , absolute neutrophil count , cancer , surgery , chemotherapy , physics , astrobiology , biology , genetics

Severe Congenital Neutropenia is a rare condition characterized by a very low neutrophil count, which pre‐disposes the affected child to recurrent bacterial infections. Treatment with granulocyte colony stimulating factor (G‐CSF) has dramatically improved the prognosis of these children; but in patients who have become G‐CSF refractory, hematopoeitic stem cell transplant is still the only effective curative treatment. We describe a patient who was unresponsive to escalating doses of G‐CSF and underwent a successful reduced intensity conditioning, matched unrelated donor allograft resulting in cure. Pediatr Blood Cancer 2008;50:920–921. © 2007 Wiley‐Liss, Inc.

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