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Development of Langerhans cell histiocytosis associated with chronic active Epstein–Barr virus infection
Author(s) -
Sakata Naoki,
Toguchi Naomi,
Kimura Masatomo,
Nakayama Masahiro,
Kawa Keisei,
Takemura Tsukasa
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21249
Subject(s) - medicine , langerhans cell histiocytosis , histiocytosis , virus , epstein–barr virus , mononucleosis , pathology , immunology , disease
Abstract Chronic active Epstein–Barr virus (CAEBV) infection is characterized by a status of lymphoproliferative disease of EBV‐infected cells, resulting in chronic or recurrent infectious mononucleosis‐like symptoms. CAEBV is always accompanied by life‐threatening complications. We report the case of a 2‐year‐old female patient with CAEBV who subsequently developed Langerhans cell histiocytosis (LCH) presenting with bilateral exophthalmos, bone, and skin involvement. In situ hybridization for EBER revealed EBV‐infected B‐cells present in lesional tissue implying that interactions between EBV‐infected B‐cells and lesional Langerhans cells may be associated with the development of LCH. Pediatr Blood Cancer 2008;50:924–927. © 2007 Wiley‐Liss, Inc.