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Graft versus leukemia effect against juvenile myelomonocytic leukemia after unrelated cord blood transplantation
Author(s) -
Tanoshima Reo,
Goto Hiroaki,
Yanagimachi Masakatsu,
Kajiwara Ryosuke,
Kuroki Fumiko,
Yokota Shumpei
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21200
Subject(s) - juvenile myelomonocytic leukemia , medicine , leukemia , cord blood , transplantation , regimen , blood cancer , concordance , juvenile , oncology , complete remission , conditioning regimen , disease , gastroenterology , chemotherapy , surgery , immunology , cancer , hematopoietic stem cell transplantation , stem cell , haematopoiesis , genetics , biology
A 13‐month‐old female underwent unrelated cord blood transplantation (CBT) for juvenile myelomonocytic leukemia (JMML). In spite of progression of the disease after a conditioning regimen with high‐dose chemotherapy, a complete remission was induced in concordance with development of acute GVHD after reduction of the immunosupressant. She has been in complete remission for 1 year after transplantation. This case illustrates that CBT can provide a potent graft versus leukemia (GVL) effect against JMML. Pediatr Blood Cancer 2008;50:665–667. © 2007 Wiley‐Liss, Inc.