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Complex chromosome 8;21 translocation with associated hyperdiploidy in acute myeloid leukemia (FAB‐M2)
Author(s) -
Corral María del Pilar,
Villa Olaya,
Alfaro Elizabeth M.,
Alonso Cristi.,
Baro Cristina,
Felice Maria S.,
Rossi Jorge,
Solé Francesc,
Gallego Marta S.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21192
Subject(s) - fluorescence in situ hybridization , chromosomal translocation , karyotype , acute myeloblastic leukemia , myeloid leukemia , medicine , comparative genomic hybridization , cancer research , chromosome , cytogenetics , microbiology and biotechnology , leukemia , biology , oncology , genetics , gene
We present a case of acute myeloblastic leukemia (AML‐M2) with a complex t(8;21) translocation and additional acquired chromosomes yielding a hyperdiploid karyotype. AML1 / ETO transcript was observed by reverse transcription‐polymerase chain reaction. Fluorescence in situ hybridization (FISH), spectral karyotyping (SKY), and comparative genomic hybridization (CGH) were performed to further identify the chromosomes observed by G banding. The patient was treated according to our current protocol for AML. He remains in complete remission +11 months from diagnosis. Further follow‐up of this patient and the analysis of a larger number of children are needed to define whether the gains of the specific extra chromosomes modify the good prognosis that t(8;21) confers to this subgroup of AML. Pediatr Blood Cancer 2008;50:651–654. © 2007 Wiley‐Liss, Inc.