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Presentation of acute promyelocytic leukemia as granulocytic sarcoma
Author(s) -
Worch Jennifer,
Ritter Jörg,
Frühwald Michael C.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21190
Subject(s) - medicine , blood cancer , acute promyelocytic leukemia , differential diagnosis , myeloid leukemia , sarcoma , leukemia , presentation (obstetrics) , myeloid , disease , pathology , myeloid sarcoma , cancer , cancer research , immunology , radiology , gene , retinoic acid , biochemistry , chemistry
Abstract Granulocytic sarcoma (GS) is a localized tumor composed of immature myeloid cells. This extramedullary tumor can present before, concurrent with or after the diagnosis of acute myeloid leukemia. GS is extremely uncommon in acute promyelocytic leukemia (APL). As a proportion of patients never develop systemic disease, correct and timely diagnosis may be rather difficult, but is a prerequisite for optimal outcome. GS should be considered in the differential diagnosis of children with unusual bone lesions. We describe a patient with GS who presented with symptoms mimicking osteomyelytis or rheumatoid disease. Pediatr Blood Cancer 2008;50:657–660. © 2007 Wiley‐Liss, Inc.