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Treatment of pediatric non‐Hodgkin lymphoma in Hungary: 15 years experience with NHL‐BFM 90 and 95 protocols
Author(s) -
Müller Judit,
Csóka Monika,
Jakab Zsuzsanna,
Ponyi Andrea,
Erlaky Hajna,
Kovács Gábor
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21144
Subject(s) - medicine , lymphoma , blood cancer , overall survival , non hodgkin's lymphoma , retrospective cohort study , hodgkin lymphoma , cancer , oncology , pediatrics
Retrospective analysis was performed to assess the survival‐rates of children with non‐Hodgkin lymphoma (NHL), treated according to the NHL‐BFM (Berlin‐Frankfurt‐Münster)‐90 and ‐95 protocols between 1990 and 2004 in Hungary, and to compare our data with the international results. Ninety‐one patients had non‐B‐NHL, 108 B‐NHL, and 31 ALCL. Complete remission rate was 89%, while 12% relapsed later. The 5‐year‐overall‐survival was 78% and the event‐free survival was 75%. These results are lower than those reported by the BFM study group, but comparable from other European centers. In the last 5 years, the results showed 10% improvement and death during induction was reduced from 10 to 3%. Pediatr Blood Cancer 2008;50:633–635. © 2007 Wiley‐Liss, Inc.