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Treatment of recurrent clear cell sarcoma of the kidney with brain metastasis
Author(s) -
Radulescu Vlad C.,
Gerrard Mary,
Moertel Chris,
Grundy Paul E.,
Mathias Liesl,
Feusner James,
Diller Lisa,
Dome Jeffrey S.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21131
Subject(s) - medicine , chemotherapy , etoposide , ifosfamide , surgery , radiation therapy , carboplatin , chemotherapy regimen , brain metastasis , regimen , metastasis , oncology , cancer , cisplatin
Background Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain. Methods A retrospective records review was conducted on eight patients with CCSK who developed brain metastases after complete responses to initial therapy. Results The recurrences occurred at a median of 24.5 months after initial diagnosis (range, 12–53 months). At the time of recurrence, patients were treated with multimodal therapy including biopsy or resection, radiation therapy, and chemotherapy. All patients received a variable number of courses of ifosfamide, carboplatin, and etoposide (ICE), with or without other agents. Four patients received high‐dose chemotherapy with autologous stem cell rescue. One patient died from complications of bacteremia 8 weeks after starting chemotherapy. The other seven patients achieved a complete response after either surgery or ICE chemotherapy. Of these, six patients were alive without disease with a median follow‐up of 30 months from the time of recurrence (range, 24 to 71 months). All six survivors received radiation therapy and four had gross total resections. Three survivors received high‐dose chemotherapy with stem cell rescue. Conclusion Patients with recurrent CCSK involving the brain can have durable survival after recurrence. ICE chemotherapy, together with radiation therapy and surgery, provides a reasonable salvage regimen for recurrent CCSK. It is unclear whether high‐dose chemotherapy confers a benefit compared to conventional‐dose chemotherapy. Pediatr Blood Cancer 2008;50:246–249. © 2007 Wiley‐Liss, Inc.