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Pulmonary dysfunction in pediatric hematopoietic stem cell transplant patients: Overview, diagnostic considerations, and infectious complications
Author(s) -
Collaco J. Michael,
Gower W. Adam,
Mogayzel Peter J.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21061
Subject(s) - medicine , hematopoietic stem cell transplantation , bronchoalveolar lavage , blood cancer , incidence (geometry) , bronchoscopy , hematopoietic stem cell , lung , stem cell , intensive care medicine , surgery , transplantation , pediatrics , haematopoiesis , cancer , physics , biology , optics , genetics
Pulmonary complications are among the most common and serious sequelae seen in hematopoietic stem cell transplantation (HSCT) recipients. This two‐part review addresses the incidence and impact of pulmonary complications in pediatric HSCT patients. In this first part we review the available data for the use of diagnostic modalities in this population, including flexible bronchoscopy with bronchoalveolar lavage (BAL) and open lung biopsy (OLB). We also review the many infectious pulmonary complications that may occur in pediatric HSCT recipients, utilizing the traditional chronologic divisions of neutropenic phase (0–30 days following HSCT), early phase (30–100 days), and late phase (>100 days). Pediatr Blood Cancer 2007;49:117–126. © 2006 Wiley‐Liss, Inc.