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Juxtaglomerular cell tumor in an 8‐year‐old girl
Author(s) -
Shao Lei,
Manalang Michelle,
Cooley Linda
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21048
Subject(s) - fluorescence in situ hybridization , medicine , pathology , kidney , population , monosomy , neoplasm , endocrinology , karyotype , biology , genetics , chromosome , environmental health , gene
Juxtaglomerular cell tumor (JGCT) is an extremely rare renal neoplasm in the pediatric population. It is considered a benign tumor arising from the juxtaglomerular apparatus of the kidney. JGCT has characteristic clinicopathologic features, but its cytogenetic features are unknown. We report a case of JGCT in an 8‐year‐old female who presented with severe hypertension, elevated serum renin level, and a well circumscribed tumor in the right kidney. Protogranules of renin was identified in the cytoplasm of the tumor cells by electron microscopic examination. Fluorescence in situ hybridization revealed monosomy of chromosomes X, 6, 9, 11, 15, and 21. Pediatr Blood Cancer 2008;50:406–409. © 2006 Wiley‐Liss, Inc.