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Acute transient encephalopathy following paclitaxel treatment in an adolescent with a recurrent suprasellar germinoma
Author(s) -
Rook James,
Rosser Tena,
Fangusaro Jason,
Finlay Jonathan
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21040
Subject(s) - medicine , paclitaxel , germinoma , encephalopathy , chemotherapy , surgery
Paclitaxel is an antineoplastic agent that is used in the treatment of a variety of solid tumors. Dose‐limiting side effects of myelosuppression and peripheral neuropathy are well known. Paclitaxel has minimal penetration of the blood‐brain barrier and central nervous system side effects are rare. However, transient encephalopathy following paclitaxel infusion has been described in adults but not in children. We present the case of a 14‐year‐old female with a recurrent suprasellar germinoma who developed an acute encephalopathy 4–6 hr following paclitaxel infusion. Pediatr Blood Cancer 2008;50:699–700. © 2006 Wiley‐Liss, Inc.