Premium
Brainstem primitive neuroectodermal tumors (bstPNET): Results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue
Author(s) -
Fangusaro Jason R.,
Jubran Rima F.,
Allen Jeffrey,
Gardner Sharon,
Dunkel Ira J.,
Rosenblum Mark,
Atlas Mark P.,
GonzalezGomez Ignacio,
Miller Douglas,
Finlay Jonathan L.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21032
Subject(s) - medicine , etoposide , vincristine , chemotherapy , induction chemotherapy , cyclophosphamide , oncology , radiation therapy , surgery
We have evaluated the response rate and survival utilizing intensified chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) and adjuvant radiation therapy in six young children with newly diagnosed brainstem primitive neuroectodermal tumors (bstPNET). Following maximum surgical resection of the tumor, patients received high dose induction chemotherapy including vincristine, cisplatin, cyclophosphamide, and etoposide. Eligible patients received a single cycle of myeloablative chemotherapy followed by AuHCR. Two patients survive at least 32 months with stable disease. This approach provides an alternative for young patients with bstPNET who in prior reports have had a uniformly fatal prognosis. Pediatr Blood Cancer 2008;50:715–717. © 2006 Wiley‐Liss, Inc.