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A comparative analysis of functional outcomes in adolescents and young adults with lower‐extremity bone sarcoma
Author(s) -
Ginsberg Jill P.,
Rai Shesh N.,
Carlson Claire A.,
Meadows Anna T.,
Hinds Pamela S.,
Spearing Elena M.,
Zhang Lijun,
Callaway Lulie,
Neel Michael D.,
Rao Bhaskar N.,
Marchese Victoria G.
Publication year - 2007
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.21018
Subject(s) - medicine , amputation , quality of life (healthcare) , sarcoma , physical therapy , physical medicine and rehabilitation , femur , prospective cohort study , surgery , pathology , nursing
Background Comparison of functional mobility and quality of life is performed in patients with lower‐extremity bone sarcoma following either amputation, limb‐sparing surgery, or rotationplasty with four different types of outcome measures: (1) an objective functional mobility measure that requires patients to physically perform specific tasks, functional mobility assessment (FMA); (2) a clinician administered tool, Musculoskeletal Tumor Society Scale (MSTS); (3) a patient questionnaire, Toronto Extremity Salvage Scale (TESS); and (4) a health‐related quality of life (HRQL) measure, Short Form‐36 version 2 (SF‐36v.2). Procedure This is a prospective multi‐site study including 91 patients with lower‐extremity bone sarcoma following amputation, limb‐sparing surgery, or rotationplasty. One of three physical therapists administered the quality of life measure (SF‐36v.2) as well as a battery of functional measures (FMA, MSTS, and TESS). Results Differences between patients who had amputation, limb‐sparing surgery, or rotationplasty were consistently demonstrated by the FMA. Patients with limb sparing femur surgery performed better than those patients with an above the knee amputation but similarly to a small number of rotationplasty patients. Several of the more conventional self‐report measures were shown to not have the discriminative capabilities of the FMA in these cohorts. Conclusion In adolescents with lower‐extremity bone sarcoma, it may be advantageous to consider the use of a combination of outcome measures, including the FMA, for objective functional mobility assessment along with the TESS for a subjective measure of disability and the SF‐36v.2 for a quality‐of‐life measure. Pediatr Blood Cancer 2007;49:964–969. © 2006 Wiley‐Liss, Inc.