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Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis
Author(s) -
Ridola Vita,
Buonuomo Paola Sabrina,
Maurizi Palma,
Putzulu Rossana,
Annunziata Maria Laura,
Pietrini Domenico,
Riccardi Riccardo
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20986
Subject(s) - hypertriglyceridemia , medicine , plasmapheresis , blood cancer , acute pancreatitis , apheresis , triglyceride , lymphoblastic leukemia , pancreatitis , gastroenterology , cancer , leukemia , immunology , cholesterol , platelet , antibody
Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10‐year‐old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associated with mild pancreatitis. Hypertriglyceridemia was successfully managed with plasmapheresis with a decrease in triglyceride levels to 590 mg/dl. Apheresis appears to be safe and effective in reducing hypertriglyceridemia and preventing related complications. Pediatr Blood Cancer 2008;50:378–380. © 2006 Wiley‐Liss, Inc.