Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis | Zendy

Ridola Vita | Zendy; Buonuomo Paola Sabrina | Zendy; Maurizi Palma | Zendy; Putzulu Rossana | Zendy; Annunziata Maria Laura | Zendy; Pietrini Domenico | Zendy; Riccardi Riccardo | Zendy

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Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis

Author(s) -

Ridola Vita,

Buonuomo Paola Sabrina,

Maurizi Palma,

Putzulu Rossana,

Annunziata Maria Laura,

Pietrini Domenico,

Riccardi Riccardo

Publication year - 2008

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.20986

Subject(s) - hypertriglyceridemia , medicine , plasmapheresis , blood cancer , acute pancreatitis , apheresis , triglyceride , lymphoblastic leukemia , pancreatitis , gastroenterology , cancer , leukemia , immunology , cholesterol , platelet , antibody

Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10‐year‐old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associated with mild pancreatitis. Hypertriglyceridemia was successfully managed with plasmapheresis with a decrease in triglyceride levels to 590 mg/dl. Apheresis appears to be safe and effective in reducing hypertriglyceridemia and preventing related complications. Pediatr Blood Cancer 2008;50:378–380. © 2006 Wiley‐Liss, Inc.

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