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Prolactinoma as the first manifestation of Gardner's syndrome
Author(s) -
Goodin Geoffrey S.,
McCarville M. Beth,
Thibodeau Stephen N.,
Skapek Stephen X.,
Khoury Joseph D.,
Spunt Sheri L.
Publication year - 2008
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20985
Subject(s) - medicine , prolactinoma , general surgery , pediatrics , hormone , prolactin
Familial adenomatous polyposis (FAP) is an inherited condition causing numerous adenomatous colorectal polyps and a markedly elevated risk of colon cancer. FAP may be associated with various extracolonic manifestations such as desmoid fibromatosis and osteomas (termed Gardner's syndrome) and brain tumors, usually medulloblastoma or glioma [termed Brain Tumor Polyposis (BTP) syndrome type 2]. We describe a pediatric patient who initially presented with prolactinoma and later was found to have Gardner's syndrome. A germline mutation of the APC (adenomatous polyposis coli) gene was identified. Our case illustrates the association between prolactinoma and FAP, which may represent a rare subtype of Gardner's and BTP syndromes. Pediatr Blood Cancer 2008;50:409–412. © 2006 Wiley‐Liss, Inc.