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Gene expression profile of idiopathic thrombocytopenic purpura (ITP)
Author(s) -
Sood Ruchira,
Wong Wendy,
Jeng Michael,
Zehnder James L.
Publication year - 2006
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.20981
Subject(s) - thrombocytopenic purpura , pathophysiology , medicine , dna microarray , gene , gene expression , blood cancer , immunology , tlr7 , cancer , genetics , platelet , immune system , biology , innate immune system , toll like receptor
To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strongly correlated with ITP. These included a cluster of interferon‐regulated genes and TLR7, as well many less‐well characterized genes which are candidates for further study. We believe this approach is likely to yield new insights into our understanding of the molecular pathophysiology of ITP. Pediatr Blood Cancer 2006;47:675–677. © 2006 Wiley‐Liss, Inc.